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研究成果 (Publications) |
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< 期刊著作 > < 引用次數 > < 研討會演講 > <研討會主持> <期刊編輯委員> <期刊審稿> <學會理事> <獲獎經歷>
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Publications in international
journals (1999–present)
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1.
Yin,
S.-J., Han, C.-L., Lee, A.-I. and Wu, C.-W. (1999)
Human alcohol dehydrogenase family: Functional classification,
ethanol/retinol metabolism, and medical implications, in “Enzymology and Molecular Biology of Carbonyl Metabolism 7,”
H. Weiner, E. Maser, D. W. Crabb and R. Lindahl, eds., Kluwer Academic/Plenum Publishers, New
York, pp. 265–274. (The book is the volume 463 of the Advances in
Experimental Medicine and Biology, 1999). 2.
Peng,
G.-S., Wang, M.-F., Chen, C.-Y., Luu, S.-U., Chou,
H.-C., Li, T.-K. and Yin, S.-J. (1999) Involvement
of acetaldehyde for full protection against alcoholism by homozygosity of the
variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 9:463–476. 3.
Duester, G., Farrés, J., Felder, M. R., Holmes, R., Höög, J.-O., Parés, X., Plapp,
B. V., Yin, S.-J. and Jörnvall,
H. (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase
gene family. Biochem. Pharmacol. 58:389–395. 4.
Osier,
M., Pakstis, A. J., Kidd, J. R., Lee, J.-F., Yin,
S.-J., Ko, H.-C., Edenberg,
H. J., Lu, R.-B. and Kidd, K. K. (1999) Linkage
disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am. J. Hum. Genet. 64:1147–1157. 5.
Lee,
J.-F., Lu, R.-B., Ko, H.-C., Chang, F.-M., Yin,
S.-J., Pakstis, A. J. and Kidd, K. K. (1999) No
association between DRD2 locus and alcoholism after controlling the ADH and
ALDH genotypes in Chinese Han population. Alcohol. Clin. Exp. Res. 23:592–599. 6.
Chen,
C.-C., Lu, R.-B., Chen, Y.-C., Wang, M.-F., Chang, Y.-C., Li, T.-K. and Yin, S.-J. (1999) Interaction between the functional
polymorphisms of the alcohol metabolism genes in protection against
alcoholism. Am. J. Hum. Genet., 65:795–807. 7.
Chen,
Y.-C., Lu, R.-B., Peng, G.-S., Wang, M.-F., Wang. H.-K., Ko,
H.-C., Chang, Y.-C., Lu, J.-J., Li, T.-K. and
Yin, S.-J. (1999) Alcohol metabolism and cardiovascular response in an
alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol. Clin. Exp. Res. 23:1853–1860. 8.
Deka, R., Shriver, M.
D., Yu, L. M., Heidreich, E. M., Jin, L., Zhong, Y., McGarvey, S. T.,
Agarwal, S. S., Bunker, C. H., Miki, T., Hundrieser,
J., Yin, S.-J., Raskin, S., Barrantes,
R., Ferrell, R. E. and Chakraborty, R. (1999) Genetic variation at
twenty-three microsatellite loci in sixteen human populations. J. Genet.
78:99–121. 9.
Lai,
C.-L., Chao, Y.-C., Chen, Y.-C., Liao, C.-S., Chen, M.-C., Liu, Y.-C. and Yin, S.-J. (2000) No sex and age influence on the
expression pattern and activities of human gastric alcohol and aldehyde
dehydrogenases. Alcohol. Clin. Exp. Res. 24:1625–1632. 10.
Li,
T.-K., Yin, S.-J., Crabb, D. W., O' Connor, S. and Ramchandani, V. A. (2001) Genetic and environmental
influences on alcohol metabolism in humans. Alcohol. Clin. Exp. Res. 25:1–9. 11.
Yin,
S.-J. and Agarwal, D. P. (2001) Functional
polymorphism of alcohol and aldehyde dehydrogenases: Alcohol metabolism,
alcoholism, and alcohol-induced organ damage, in “Alcohol in Health and
Disease,” D. P. Agarwal and H. K. Seitz, eds., Marcel Dekker, New York, pp.
1–26. 12.
Chou,
C.-F, Lai, C.-L., Chang, Y.-C., Duester, G. and
Yin, S.-J. (2002) Kinetic mechanism of human class IV alcohol dehydrogenase
functioning as retinol dehydrogenase. J. Biol. Chem. 277:25209–25216. 13.
Peng,
G.-S., Yin, J.-H., Wang, M,-F., Lee, J.-T., Hsu, Y.-D. and
Yin, S.-J. (2002) Alcohol sensitivity in Taiwanese men with different alcohol
and aldehyde dehydrogenase genotypes. J. Formosan Med. Assoc. 101:769–774. 14.
Yin,
S.-J., Chou, C.-F., Lai, C.-L., Lee, S.-L. and Han,
C.-L (2003) Human class IV alcohol dehydrogenase: kinetic mechanism,
functional roles and medical relevance. Chem. Biol. Interact. 143–144:219–227. 15.
Lee,
S.-L., Wang, M.-F., Lee, A.-I. and Yin, S.-J. (2003)
The metabolic role of human ADH3 functioning as ethanol dehydrogenase. FEBS Lett. 544:143–147. 16.
Huang,
S.-Y., Lin, W.-W., Ko, H.-C., Lee, J.-F., Wang,
T.-J., Chou, Y.-H., Yin, S,-J. and Lu, R.-B. (2004) Possible interaction of
alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2
receptor gene in anxiety-depressive alcohol dependence. Alcohol. Clin. Exp. Res. 28:374–384. 17.
Lee,
S.-L., Höög, J.-O. and
Yin, S.-J. (2004) Functionality of allelic variations in human alcohol
dehydrogenase gene family: Assessment of a functional window for protection
against alcoholism. Pharmacogenetics 14:725–732. 18.
Yin,
S.-J. and Peng, G.-S. (2005) Overview of ALDH
polymorphism: Relation to cardiovascular effects of alcohol, in “Comprehensive
Handbook of Alcohol Related Pathology,” V. R. Preedy
and R. R. Watson, eds., vol.1, Elsevier Academic Press, London, pp. 411–426. 19.
Ma,
L.-C., Lee, S.-L., Lee, C.-Z., Yin, S.-J. and Wang,
J.-T. (2005) Molecular cloning and kinetic characterization of an aldehyde
dehydrogenase gene in Klebsiella pneumoniae. J. Formosan
Med. Assoc. 104:221–230. 20.
Peng,
F.-C., Tang, S.-H., Huang, M.-C., Chen, C.-C., Kuo,
T.-L. and Yin, S.-J. (2005) Oxidative status in
patients with alcohol dependence: A clinical study in Taiwan. J. Toxicol.
Environ. Health 68:1497–1509. 21.
Yin,
S.-J., Lee, S.-L., Han, C.-L., Chou, C.-F. and Wang,
M.-F. (2006) Pharmacogenetic determinants of
alcohol metabolism and alcoholism in human alcohol dehydrogenase family, in “Enzymology and Molecular Biology of Carbonyl Metabolism 12,”
H. Weiner, R. Lindahl, B. V. Plapp and E. Maser,
eds., Purdue University Press, West Lafayette, pp. 161–170. 22.
Lee,
S.-L., Chau, G.-Y., Yao, C.-T., Wu, C.-W. and Yin,
S.-J. (2006) Functional assessment of human alcohol dehydrogenase family in
ethanol metabolism: Significance of first-pass metabolism. Alcohol. Clin.
Exp. Res. 30:1132–1142. 23.
Lee,
S.-P., Chiang, C.-P., Lee, S.-L., Hsia, Y.-J., Chuang, T.-L., Lin, J.-C.,
Liang, S.-C., Nieh, S. and Yin, S.-J. (2006) Immunochemical
features in the classification of human alcohol dehydrogenase family. Alcohol 39:13–20. 24.
Yin,
S.-J. and Peng, G.-S. (2007) Acetaldehyde,
polymorphisms and cardiovascular system, in “Acetaldehyde-related Pathology:
Bridging the Trans-disciplinary Divide,” Novartis (formerly Ciba)
Foundation Symposia 285, D. J. Chadwick and J. Goode, eds., John Wiley &
Sons Ltd., Chichester, UK, pp. 52–63; Discussion,
pp. 63–68. 25.
Yin,
S.-J., Lee, S.-L., Yao, C.-T. and Lai, C.-L. (2007)
Functional roles of alcohol dehydrogenases in human ethanol metabolism, in “Enzymology and Molecular Biology of Carbonyl Metabolism 13,”
H. Weiner, E. Maser, R. Lindahl and and B. V. Plapp, eds., Purdue University Press,
West Lafayette,pp. 134–143. 26.
Peng,
G.-S., Yin, S.-J., Cheng, C.-A., Chiu, S.-W., Lee, J.-T., Lin, W.-W., Lin,
J.-C. and Hsu, Y.-D. (2007) Increased risk of
cerebral haemorrhage in Chinese male heavy drinkers
with mild liver disorder. Cerebrovasc. Dis.23:309–314. 27.
Peng,
G.-S., Chen, Y.-C., Tsao, T.-P., Wang, M.-F. and Yin, S.-J. (2007) Pharmacokinetic and pharmacodynamic basis for partial against alcoholism an Asians, heterozygous for the variant ALDH2*2 gene. Pharmacogenet.
Genomics 17:845–855. 28.
Chen,
C.-C. and Yin, S-J. (2008) Alcohol abuse and related
factors in Asia. Int.
Rev. Psychiatry 20:425–433. 29.
Peng,
G.-S. and Yin, S.-J. (2009) Effect of the allelic
variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2
on blood acetaldehyde concentrations. Hum. Genomics 3:121–127. 30.
Chen,
Y.-C, Peng, G.-S., Wang, M.-F., Taso, T.-P. and Yin, S.-J. (2009) Polymorphism of ethanol-metabolism
genes and alcoholism: Correlation of allelic variations with the
pharmacokinetic and pharmacodynamic consequences. Chem. Biol.
Interact.178:2–7. 31.
Wang,
M-F., Han, C.-L. and Yin, S.-J. (2009) Substrate
specificity of human and yeast aldehyde dehydrogenases. Chem. Biol.
Interact.178:36–39. 32.
Chiang,
C.-P., Wu, C.-W., Lee, S.-P., Chung, C.-C., Wang, C.-W., Lee, S.-L., Nieh, S. and Yin, S.-J. (2009) Expression pattern,
ethanol-metabolizing activities, and cellular localization of alcohol and
aldehyde dehydrogenases in human pancreas: Implications for pathogenesis of
alcohol-induced pancreatic injury. Alcohol. Clin. Exp. Res. 33:1059–1068. 33.
Chen,
Y.-C., Peng, G.-S., Tsao, T.-P., Wang, M.-F., Lu,
R.-B. and Yin, S.-J. (2009) Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced
adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2
gene allele. Pharmacogenet.
Genomics 19:588–599. 34.
Yao,
C.-T., Lai, C.-L., Hsieh, H.-S., Chi, C.-W. and Yin,
S.-J. (2010) Establishment of steady-state metabolism of ethanol in perfused
rat liver: The quantitative analysis using kinetic mechanism-based rate
equations of alcohol dehydrogenase. Alcohol
44:541–551. 35.
Lee,
S.-L., Shih, H.-T., Chi, Y.-C., Li. Y.-P. and Yin,
S.-J. (2011) Oxidation of methanol, ethylene glycol, and isopropanol with
human alcohol dehydrogenases and the inhibition by ethanol and
4-methylpyrazole. Chem. Biol. Interact. 191:26–31. 36.
Yao,
C.-T., Cheng, C.-A., Wang, H.-K., Chiu, S.-W., Chen, Y.-C., Wang, M.-F., Yin,
S.-J. and Peng, G.-S. (2011) The role of ALDH2
and ADH1B polymorphism in alcohol consumption and stroke in Han
Chinese. Hum. Genomics 5:569–576. 37.
Chiang,
C.-P., Jao, S.-W., Lee, S.-P., Chen, P.-C., Chung,
C.-C., Lee, S.-L., Nieh, S. and Yin, S.-J. (2012)
Expression pattern, ethanol-metabolizing activities, and cellular
localization of alcohol and aldehyde dehydrogenases in human large bowel:
Association of the functional polymorphisms of ADH and ALDH genes with
hemorrhoids and colorectal cancer. Alcohol
46:37–49. 38.
Chiang,
C.-P., Wu, C.-W., Lee, S.-P., Ho, J.-L., Lee, S.-L., Nieh,
S. and Yin, S.-J. (2012) Expression pattern, ethanol-metabolizing activities,
and cellular localization of alcohol and aldehyde dehydrogenases in human
small intestine. Alcohol. Clin.
Exp. Res.
36:2047–2058. 39.
Lai,
C.-L., Li, Y.-P., Liu, C.-M., Hsieh, H.-S. and Yin,
S.-J. (2013) Inhibition of human alcohol and aldehyde dehydrogenases by
cimetidine and assessment of its effects on ethanol metabolism. Chem. Biol.
Interact. 202:275–282. 40. Li,
Y.-P., Liao, C.-L., Cheng, Y.-W., Wu, T.-L., Lee, S.-L., Liu, J.-K. and Yin, S.-J. (2013) Inhibition of human alcohol and
aldehyde dehydrogenases by acetaminophen: Assessment of the effects on
first-pass metabolism of ethanol. Alcohol
47:559–565. 41. Lai,
C.-L., Yao, C.-T., Chau, G.-Y., Yang, L.-F., Kao, T.-Y., Chiang, C.-P. and Yin, S.-J. (2014) Dominance of the inactive Asian
variant over activity and protein contents of mitochrondrial
aldehyde dehydrogenase 2 in human liver. Alcohol.
Clin. Exp. Res. 38:44–50. 42.
Peng, G.-S., Chen, Y.-C., Wang, M.-F., Lai, C.-L. and
Yin, S.-J. (2014) ALDH2*2 but not ADH1B*2 is a causative
variant gene allele for Asian alcohol flushing after a low dose challenge:
Correlation of the pharmacokinetic and pharmacodynamic
findings. Pharmacogenet. Genomics 24:607–617. 43. Yao, C.-T., Lai,
C.-L. and Yin, S.-J. (2015) Steady state metabolism
of ethanol in perfused rat livers treated with cyanamide:
Quantitative analysis of acetaldehyde effects on the metabolic flux rates. Alcohol. Clin. Exp. Res.
39:798–807. 44. Lee,
S.-L., Lee, Y.-P., Wu, M.-L., Chi, Y.-C., Liu, C.-M., Lai, C.-L. and Yin, S.-J. (2015) Inhibition of human alcohol and
aldehyde dehydrogenases by aspirin and salicylate: Assessment of the effects
on first-pass metabolism of ethanol. Biochem. Pharmacol. 95:71–79. 45.
Chiang, C.-P., Lai, C.-L., Lee, S.-P., Hsu, W.-L., Chi, Y.-C., Gao, H.-W.,
Yao, C.-T., Chou, G.-Y. and Yin, S.-J. (2016)
Ethanol metabolizing activities and isozyme protein contents of alcohol and
aldehyde dehydrogenases in human liver: Phenotypic traits of the ADH1B*2 and ALDH2*2 variant gene alleles. Pharmacogenet.
Genomics 26:184‒195. 46. Chi, Y.-C., Lee, S.-L., Lai, C.-L., Lee, Y.-P.,
Lee, S.-P., Chiang, C.-P., and Yin, S.-J. (2016) Ethanol oxidation and the
inhibition by drugs in human liver, stomach and small intestine: Quantitative
assessment with numerical organ modeling of alcohol dehydrogenase isozymes. Chem. Biol. Interact. 258:134‒141. |
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引用次數 |
Citations
(Google Scholar search; accessed: 22 December 2011) |
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Total citations: > 2790 (≥ 100-citation
articles, 6 (6.3% for the total 95 publications); ≥ 40-citation articles, 19
(20.0%); ≥ 25-citation articles, 30 (31.6%)) |
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The most cited articles ( ≥ 25 citations; 1 star represents 25 accumulated citations per article, e.g., an article with 25 to 49 citations has 1 star and that with 50 to 74 citations, 2 stars, and so on; sum: 87 stars. This is one of the evaluation ways for intramural performance by the National Institutes of Health, USA, to assess quality of published articles, i.e., impact factor of the articles per se rather than that of the publishing journals, symposium proceedings, monographs, books.) 1. Alcohol
and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am. J.
Hum. Genet. 48:677-681, 1991 (441 citations; 17 stars). 2. Interaction
between the functional polymorphisms of the alcohol-metabolism genes in
protection against alcoholism. Am. J. Hum. Genet. 65:795–807, 1999 (264
citations; 10 stars). 3. Recommended
nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem. Pharmacol. 58:389–395,
1999 (164 citations; 6 stars). 4. Linkage
disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am. J. Hum.
Genet. 64:1147–1157, 1999 (163 citations; 6 stars). 5. Polymorphism
of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in
Chinese patients. Hepatology 19:360-366, 1994 (140 citations; 5 stars). 6. Low
frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol
use disorders. Alcohol. Clin. Exp. Res. 18:640-643,
1994 (101 citations; 4 stars). 7. Alcohol
and aldehyde dehydrogenases in human esophagus: Comparison with the stomach
enzyme activities. Alcohol. Clin. Exp. Res.
17:376-381, 1993 (89 citations; 3 stars). 8. Genetic
and environmental influences on alcohol metabolism in humans. Alcohol. Clin. Exp. Res. 25:136–144, 2001 (87 citations; 3 stars). 9. Human
liver alcohol dehydrogenase: Purification and kinetic characterization of the
beta2beta2, beta2beta1, alpha beta2, and beta2gamma1 “Oriental” isoenzymes.
Biochemistry 23:5847-5853, 1984 (84 citations; 3 stars). 10. Involvement of
acetaldehyde for full protection against alcoholism by homozygosity of the
variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.
Pharmacogenetics 9:463–476, 1999 (82 citations; 3 stars). 11. Human stomach
alcohol and aldehyde dehydrogenases: Comparison of expression pattern and
activities in alimentary tract. Gastroenterology 112:766-775, 1997 (80
citations; 3 stars). 12. Contribution to
first-pass metabolism of ethanol and inhibition by ethanol for retinol
oxidation in human alcohol dehydrogenase family: Implications for etiology of
fetal alcohol syndrome and alcohol-related diseases. Eur. J. Biochem. 254:25-31, 1998 (71 citations; 2 stars). 13. Alcohol metabolism
and cardiovascular response in an alcoholic patient homozygous for the
ALDH2*2 variant gene allele. Alcohol. Clin. Exp.
Res. 23:1853–1860, 1999 (69 citations; 2 stars). 14. Expression and activities
of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in
human mouth. Alcohol 13:257-262, 1996 (64 citations; 2 stars). 15. Possible
interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with
the dopamine D2 receptor gene in anxiety-depressive alcohol dependence.
Alcohol. Clin. Exp. Res. 28:374–384, 2004 (54
citations; 2 stars). 16. Identification of a
human stomach alcohol dehydrogenase with distinctive kinetic properties. Biochem. Int. 22:829-835, 1990 (63 citations; 2 stars). 17. Genetic variation
at twenty-three microsatellite loci in sixteen human populations. J. Genet.
78:99–121, 1999 (43 citations; 1 star). 18. Alcohol
dehydrogenase: Enzymology and metabolism. Alcohol Alcohol.
29 (Suppl. 2):113-119. (The title of
the Supplement is “The Biology of Alcohol Problems,” J. B. Saunders and J. B.
Whitfield, eds., Elsevier Science, Oxford, 1996), 1994 (40 citations; 1 star) . 19. Genetic
polymorphism and activities of human colon alcohol and aldehyde dehydrogenases:
No gender and age differences. Alcohol. Clin. Exp.
Res. 18:1256-1260, 1994 (40 citations; 1 star). 20. Distribution and
evolution of CTG repeats at the myotonin protein
kinase gene in human populations. Genome Res. 6:142-154, 1996 (36 citations;
1 star). 21. Human stomach
alcohol and aldehyde dehydrogenases(ALDH): A genetic
model proposed for ALDH III isoenzymes. Biochem.
Genet. 26:343-360, 1988 (34 citations; 1 star). 22. Kinetic mechanism
of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase.
J. Biol. Chem. 277:25209–25216, 2002 (31 citations; 1 star). 23. Alcohol sensitivity
in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes.
J. Formos. Med. Assoc. 101:769–774, 2002 (31
citations; 1 star). 24. Structural features
of stomach aldehyde dehydrogeanse distinguish
dimeric aldehyde dehydrogenase as a ‘variable’ enzyme: ‘Variable’ and
‘constant’ enzymes within the alcohol and aldehyde dehydrogenase families.
FEBS Lett. 283:85-88, 1991 (30
citations; 1 star). 25. Pseudomonas 3β-hydroxysteroid dehydrogenase: Primary structure and
relationship to steroid dehydrogenases. Eur. J. Biochem.
197:359-365, 1991 (29 citations; 1 star). 26. Functional
polymorphism of alcohol and aldehyde dehydrogenases: Alcohol metabolism,
alcoholism, and alcohol-induced organ damage, in “Alcohol in Health and
Disease,” D. P. Agarwal and H. K. Seitz, eds., Marcel Dekker, New York, pp.
1–26, 2001 (27 citations; 1 star). 27. No association
between DRD2 locus and alcoholism after controlling the ADH and ALDH
genotypes in Chinese Han population. Alcohol. Clin.
Exp. Res. 23:592–599, 1999 (27 citations; 1 star). 28. Functional
assessment of human alcohol dehydrogenase family in ethanol metabolism:
Significance of first-pass metabolism. Alcohol. Clin.
Exp. Res. 30:1132–1142, 2006 (26 citations; 1 star). 29. Human alcohol
dehydrogenase family: Functional classification, ethanol/retinol metabolism,
and medical implications, in “Enzymology and Molecular Biology of Carbonyl
Metabolism 7,” H. Weiner, E. Maser, D. W. Crabb and
R. Lindahl, eds., Kluwer Academic/Plenum
Publishers, New York, pp. 265–274. (The book is Volume 463 of the Advances in
Experimental Medicine and Biology, 1999) (26 citations; 1 star). 30. Genetic polymorphism and
activities of human lung alcohol and aldehyde dehydrogenases: Implications
for ethanol metabolism and cytotoxicity. Biochem.
Genet. 30:203-215,
1992 (25 citations; 1 star). |
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研討會演講 |
Presentations
as invited speaker in international conferences |
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1.
Alcohol
and aldehyde dehydrogenase isoenzymes in human tissues: Implications for
ethanol metabolism and toxicity. (International Symposium for Biomedical
Research on Alcoholism, Taipei, Taiwan, Republic of China, 4–6 July 1988.) 2.
Human
high-Km aldehyde dehydrogenase (ALDH3): Genetic, kinetic and structural
features. (6th International Workshop on the Enzymology and Molecular Biology
of Carbonyl Metabolism, Dublin, Ireland, 28 June–1 July 1992.) 3.
Alcohol
and aldehyde dehydrogenase genotypes in Chinese alcoholic cirrhotics.
(In Symposium: Alcohol Metabolism and Genetics, 4th Congress of the European
Society for Biomedical Research on Alcoholism, Genoa, Italy, 2–5 June 1993.) 4.
Alcohol
dehydrogenase: Enzymology and metabolism. (In Symposium: Alcohol and Aldehyde
Metabolizing Systems, 7th Congress of the International Society for
Biomedical Research on Alcoholism, Gold Coast, Australia, 26 June–1 July
1994.) 5.
Substrate
binding pocket structure of human aldehyde dehydrogenase: A substrate
specificity approach. (7th International Workshop on the Enzymology and
Molecular Biology of Carbonyl Metabolism, Palmerston North, New Zealand, 3–7
July 1994.) 6.
Expression,
activities and kinetic mechanism of human stomach alcohol dehydrogenase. (8th
International Workshop on the Enzymology and Molecular Biology of Carbonyl
Metabolism, Deadwood, South Dakota, USA, 29 June–3 July 1996.) 7.
Subjective
feeling, cardiovascular responses and alcohol metabolism in subjects with
different ALDH2 genotypes: Evidence for mutant ALDH2*2 homozygosity as
completely alcohol-rejecting gene status. (European Society for Biomedical
Research on Alcoholism Nordmann Award Meeting:
Interaction of Alcohol and Drugs, Vienna, Austria, 17–18 October 1996.) 8.
Genetic
polymorphism and activity of human liver alcohol and aldehyde dehydrogenases:
Inference for first-pass metabolism of ethanol. (In Symposium: Molecular
Aspects of Alcohol Metabolism, 6th Congress of the European Society for
Biomedical Research on Alcoholism, Stockholm, Sweden, 28 June–1 July 1997.) 9.
Steady-state
kinetic mechanism of human alcohol dehydrogenase family. Implications for
functional classification and ethanol/retinol metabolism. (9th International
Symposium on the Enzymology and Molecular Biology of Carbonyl Metabolism, Varallo Sesia, Italy, 20–24
June 1998.) 10.
Allelic
variation of the alcohol dehydrogenase genes and alcoholism in Asians. (In
Symposium: Molecular Biology of the Alcohol Dehydrogenases, 9th Congress of
the International Society for Biomedical Research on Alcoholism, Copenhagen,
Denmark, 27 June–2 July 1998.) 11.
Interaction
of functional polymorphisms of alcohol metabolic genes and alcohol metabolism
in Asian alcoholics. (1999 International Titisee
Symposium on Health Effects of Alcohol Intake, Black Forest, Germany, 9–12
December 1999.) 12.
ALDH2
polymorphism and alcohol metabolism. (In Symposium: Genetic and Environmental
Influences on Alcohol Metabolism in Humans, 23rd Annual Scientific Meeting of
the Research Society on Alcoholism, Denver, U.S.A., 24–29 June 2000.) 13.
Dominance
of human ALDH2*2 variant gene allele: Influence on
liver enzyme activity/content, alcohol pharmacokinetics, and susceptibility to
alcoholism. (10th International Symposium on the Enzymology and Molecular
Biology of Carbonyl Metabolism, Taos, New Mexico, U.S.A., 1–5 July 2000.) 14.
Alcohol
dehydrogenase family and first-pass metabolism of ethanol. (In Symposium:
Basic and Clinical Aspects of Gastrointestional
Metabolism of Ethanol, 8th Congress of the European Society for Biomedical
Research on Alcoholism, Paris, France, 15–18
September 2001.) 15.
Kinetic
mechanism of human class IV alcohol dehydrogenase (ADH4) functioning as retinol
dehydrogenase: Relevance for perturbation of retinoic acid synthesis by
ethanol consumption. (11th International Meeting on Enzymology and Molecular
Biology of Carbonyl Metabolism, Ystad, Sweden, 2–6
July 2002.) 16.
The
human ADH family: Enzymology and metabolism of ethanol and retinol. (In
Symposium: Interaction of Alcohol and Retinoids:
Basic and Clinical Aspects, 9th Congress of the European Society for
Biomedical Research on Alcoholism, Prague, Czech, 11–14 September 2003.) 17.
Pharmacogenetic determinants of
alcohol metabolism and alcoholism in human alcohol dehydrogenase family.
(12th International Meeting on Enzymology and Molecular Biology of Carbonyl
Metabolism, Burlington, Vermont, U.S.A., 6–10 July 2004.) 18.
Physiological
basis for full versus partial protection against alcoholism in Asians. (In
Symposium: Acetaldehyde and Alcoholism: Basic and Clinical Perspectives, 10th
Congress of the European Society for Biomedical Research on Alcoholism,
Canterbury, U.K., 4–7 September 2005.) 19.
Functional
roles of alcohol dehydrogenase family in human ethanol metabolism. (13th
International Meeting on Enzymology and Molecular Biology of Carbonyl
Metabolism, Nashville, Indiana, U.S.A., 11–15 July 2006.) 20.
Acetaldehyde,
polymorphisms and the cardiovascular system. (Novartis (formerly Ciba)
Foundation Symposium No. 285. Acetaldehyde-related Pathology: Bridging the
Trans-disciplinary Divide, London, U.K., 5–7 September 2006.) 21.
Polymorphisms
in ADH/ALDH genes and the phenotypic correlations (In Symposium: Genetic
Approaches to Alcohol Dependency, 11th Congress of the European Society for
Biomedical Research on Alcoholism, Berlin, Germany, 23–26 September 2007.) 22.
Pharmacokinetic
and pharmacodynamic effects of acetaldehyde in
ALDH2*2 alcoholics. (In Symposium: Acetaldehyde, Alcohol-induced Behaviours and Alcoholism: Clinical and Experimental
Perspectives, 11th Congress of the European Society for Biomedical Research
on Alcoholism, Berlin, Germany, 23–26 September 2007.) 23.
Polymorphism
of alcohol-metabolism genes and alcoholism in Taiwanese: Correlation of the
allelic variations with the pharmacokinetic and pharmacodynamic
effects of acetaldehyde. (In Symposium: Alcohol Research in Asian Pacific
Countries, Joint Scientific Meeting of 19th Conference of the Japanese
Society for Psychiatric Research on Alcoholism, 42nd Conference of the
Japanese Medical Society for Psychiatric Research Studies, and 10th
Conference of the Japanese Research Forum on Nicotine and Drug Dependences
Studies, Ohtsu, Japan, 28–29 September 2007.) 24.
Pharmacokinetic
and pharmacodynamic effects of acetaldehyde in
Asian alcoholics carrying the variant ALDH2*2 gene allele. (In Symposium:
Genetic Determinants of Subjective and Physiological Responses to Ethanol and
the Risk for Alcohol Use Disorders in Asians, Joint Congress of 31st Annual
Scientific Meeting of the Research Society on Alcoholism and 14th Congress of
the International Society for Biomedical Research on Alcoholism, Washington,
DC, U,S.A., 27 June–2 July 2008.) 25.
Polymorphism
of ethanol-metabolism genes and alcoholism in Asians: Correlation of allelic
variations with the pharmacokinetic and pharmacodynamic
consequences. (14th International Meeting on Enzymology and Molecular Biology
of Carbonyl Metabolism, Kranjska Gora, Slovenia,
8–12 July 2008.) 26.
Pharmacogenetics
of human ethanol metabolism and alcoholism. (3rd Asia-Pacific City Forum of
Biomedical Laboratory Science, Taipei, 1-2 May 2010.) 27.
Quantitative
interpretation of steady-state ethanol metabolism in perfused rat liver using
the kinetic mechanism-based rate equations of alcohol dehydrogenase. (15th
International Meeting on Enzymology and Molecular Biology of Carbonyl
Metabolism, Lexington, U.S.A., 6-11 July 2010.) 28.
Pharmacokinetics and the brain hemodynamic and subjective perception effects
of acetaldehyde in heterozygous ALDH2*1/*2 alcoholics. (In ESBRA-APSAAR Joint
Symposium: Morphological Alterations in the Brain of Alcoholics, 13th
Congress of the European Society for Biomedical Research on Alcoholism,
Vienna, Austria, 4-7 September 2011.) 29. Expression pattern,
activities and protein contents of alcohol and aldehyde dehydrogenases in
human liver: Assessment of hepatic first-pass metabolism of ethanol. (16th
International Meeting on Enzymology and Molecular Biology of Carbonyl
Metabolism, Ploen, Germany, 10-14 July 2012.) Presentations
as invited speaker in national conferences |
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1.
Genetic
polymorphism and kinetic properties of human stomach alcohol and aldehyde dehydrogenases.
(Taiwan-US Biomedical Workshop on Alcoholism and Depression, Taipei, 17–18
September 1990) 2.
Alcohol
metabolism and alcoholism. (Annual Joint Academic Conference of the Formosan
Medical Association, Taipei, 11–12 November 1999) 3.
Interaction
between the functional polymorphisms of the alcohol metabolic genes in
protection against alcoholism. (Frontier in Genomic Medicine, Taipei, 29–31
May 2000) 4.
Genetics
of alcoholism and drinking behavior. (19th Bioretreat,
Taichung, 27–29 August 2003) 5.
Pharmacogenetic determinants of
alcohol metabolism and alcoholism. (plenary speaker, Substance Abuse
Symposium, Tainan, 26 February 2005) 6.
Pharmacogenetics
of alcohol metabolism and alcoholism. (Taiwan-US Workshop on Alcohol and
Health Research: From Epidemiological Survey to Genetic Diversity, Taipei, 30
September 2009) 7.
Enzymology of human ethanol metabolism. (Taiwan Enzyme Mechanism Conference,
Academia Sinica, Taipei, 15 December 2009) |
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Organizer/chair
of symposium in the international conferences |
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1.
Chairs:
Jan-Olov Höög, Sweden,
and Shih-Jiun Yin, Taiwan 2.
Chair:
Shih-Jiun Yin, Taiwan 3.
Organizer:
Shih-Jiun Yin, Taiwan; Co-organizers: Albert Y.
Sun, U.S.A., and Ting-Kai Li, U.S.A. 4.
Chairs:
Helmut K. Seitz, Germany, and Shih-Jiun Yin,
Taiwan 5.
Organizers
and Chairs: Thomas M. Badger, U.S.A., and Shih-Jiun
Yin, Taiwan 6.
Chair:
Shih-Jiun Yin, Taiwan 7.
Chairs:
Shih-Jiun Yin, Taiwan, and Helmut K. Seitz,
Germany 8.
Chair:
Shih-Jiun Yin, Taiwan 9.
Chairs:
Shih-Jiun Yin, Taiwan, and Mikko Salaspuro, Finland 10.
Chair:
Shih-Jiun Yin, Taiwan 11.
Chairs:
Etienne Quertemont, Belgium, and Shih-Jiun Yin, Taiwan 12.
Chairs:
Shih-Jiun Yin, Taiwan, and Sung-Gon
Kim, Korea 13.
Chairs: Shih-Jiun Yin, Taiwan, and Susumu Higuchi,
Japan |
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Editorial
board of academic journals |
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1.
Member
of advisory editorial board of the Journal of the Chinese Biochemical Society
(official journal of the Chinese Biochemical Society, Taiwan; 1991-1996). 2.
Assistant
editor of Addiction Biology (an official journal of the Society for the Study
of Addiction to Alcohol and Other Drugs, U.K.; 1996–2004). 3.
Guest
co-editor of a special issue for the Journal of Biomedical Science, “Alcohol:
Mode of Actions and Clinical Perspectives”, vol. 8, pp. 1–150, 2001
(published by S. Karger, Basel, Switzerland). 4.
Editor-in-chief
of the Journal of Medical Sciences (a bimonthly journal, both in print and
free online, has been published by the National Defense Medical Center,
Taipei, since 1975; 2002–2008). 5.
Member of
editorial board of the Alcoholism: Clinical and Experimental Research
(official journal of the Research Society on Alcoholism, U.S.A. and the
International Society for Biomedical Research on Alcoholism; 2008–2011). 6.
Member of board of field editors of the Alcoholism: Clinical and Experimental
Research (official journal of the Research Society on Alcoholism, U.S.A. and
the International Society for Biomedical Research on Alcoholism; 2011–2014). |
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Ad
hoc referee for international scientific journals |
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Addiction Biology; Alcohol;
Alcohol and Alcoholism; Alcoholism: Clinical and Experimental Research;
American Journal of Physiology (AJP-Gastrointestinal and Liver Physiology); Biochimica et Biophysica Acta (BBA-Molecular Basis of Disease); Biological
Psychiatry; Chemico-Biological Interactions;
Clinical Chemistry and Laboratory Medicine; Clinical Medicine and Research;
Drug and Alcohol Dependence; European Journal of Biochemistry; Experimental
and Molecular Pathology; FEBS Journal (formerly European Journal of
Biochemistry); Free Radical Biology and Medicine; Gene; Human Genomics;
Journal of Biomedical Science; Journal of Food and Drug Analysis; Journal of
Gastroenterology and Hepatology; Journal of Nutrigenetics
and Nutrigenomics; Journal of Proteomics; Neuroscience and Neurobehavior Reviews; Nutrition and Cancer;
Pharmacogenetics and Genomics; Progress in Neuro-Psychopharmacology and
Biological Psychiatry |
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Board
of directors of academic societies |
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1.
Taiwan
Society for Biochemistry and Molecular Biology (2001–2004) 2.
Asia–Pacific
Society for Alcohol and Addiction Research (founding member; 2008–2012) 3.
International Society for Biomedical Research on Alcoholism (2010–2014) |
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Awards |
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1. Research Grant Awards (1985–2012, continuous without interruptions), National Science Council of the Republic of China 2. Excellent Research Award
(1990 and 1991), National Science Council of the Republic of China 3. Outstanding Research
Award (2000), National Science Council of the Republic of China |
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