National Defense Medical Center
Personal introduction
Shih-Jiun Yin (尹士俊), Ph.D.
Honorary
Professor, Department of Biochemistry
E-mail:
yinsj@ndmctsgh.edu.tw or yinsj@ndmc.idv.tw
◎Education
·
Ph.D., Indiana University, U.S.A.
·
M.S., National Defense Medical Center, Taiwan
·
B.S., National Chung-Hsing University, Taiwan
◎Professional Experiences
·
Honorary Professor, Department of Biochemistry, National Defense Medical
Center, Taiwan (2012-present)
·
Professor, Department of Biochemistry, National Defense Medical Center,
Taiwan (1989-2012)
·
Head, Department of Biochemistry, National Defense Medical Center, Taiwan
(1990-1996)
·
Chief, Biochemistry Research Laboratory, Tri-Service General Hospital,
Taiwan (1984-1997)
·
Visiting Professor, Alcohol Research Center, Indiana University Medical
Center, U.S.A. (September-December 1992)
·
Visiting Scientist, Department of Chemistry I, Karolinska
Institute, Sweden (March-September 1989)
·
Associate Professor, Department of Biochemistry, National Defense Medical
Center, Taiwan (1984-1988)
·
Instructor, Department of Biochemistry, National Defense Medical Center,
Taiwan (1978-1980)
·
Assistant Investigator, Biochemistry Research Laboratory, Tri-Service
General Hospital, Taiwan (1974-1978)
·
Teaching Assistant, Department of Botany, National Chung-Hsing University, Taiwan (1970-1972)
◎Research Interests
Dr. Yin
has long term interests in (1) molecular enzymology of human alcohol
dehydrogenase family and aldehyde dehydrogenase family, (2) pharmacogenetics of
human ethanol metabolism and alcoholism, and (3) pathogenetic
mechanisms of alcohol-related organ injury.
Ongoing research work includes elucidation of kinetic mechanisms of human
alcohol and aldehyde dehydrogenase families and computer simulations of ethanol
metabolism in human liver, expression and cellular localization of alcohol and
aldehyde dehydrogenases in human target tissues, and pharmacokinetic and pharmacodynamic basis for full versus partial protection
against alcoholism by polymorphisms of the gene alleles of alcohol and aldehyde
dehydrogenases.
◎Research Activities &
Accomplishments
Dr.
Yin’s laboratory has made major contributions in pharmacogenetics of ethanol
metabolism and alcoholism. For the past decades he has given lectures in
important international symposia and served on editorial boards of scientific
and medical journals as follows.
A.
Presentations as invited speaker in international conferences
1.
Alcohol and aldehyde dehydrogenase isoenzymes in human tissues:
Implications for ethanol metabolism and toxicity. (International Symposium for
Biomedical Research on Alcoholism, Taipei, Taiwan, 4-6 July 1988.)
2.
Human high-Km aldehyde dehydrogenase (ALDH3): Genetic, kinetic and
structural features. (6th International Workshop on the Enzymology and
Molecular Biology of Carbonyl Metabolism, Dublin, Ireland, 28 June-1 July 1992.)
3.
Alcohol and aldehyde dehydrogenase genotypes in Chinese alcoholic cirrhotics. (In Symposium: Alcohol Metabolism and Genetics,
4th Congress of the European Society for Biomedical Research on Alcoholism,
Genoa, Italy, 2-5 June 1993.)
4.
Alcohol dehydrogenase: Enzymology and metabolism. (In Symposium: Alcohol
and Aldehyde Metabolizing Systems, 7th Congress of the International Society
for Biomedical Research on Alcoholism, Gold Coast, Australia, 26 June-1 July 1994.)
5.
Substrate binding pocket structure of human aldehyde dehydrogenase: A
substrate specificity approach. (7th International Workshop on the Enzymology
and Molecular Biology of Carbonyl Metabolism, Palmerston North, New Zealand, 3-7 July 1994.)
6.
Expression, activities and kinetic mechanism of human stomach alcohol
dehydrogenase. (8th International Workshop on the Enzymology and Molecular
Biology of Carbonyl Metabolism, Deadwood, South Dakota, USA, 29 June-3 July 1996.)
7.
Subjective feeling, cardiovascular responses and alcohol metabolism in
subjects with different ALDH2 genotypes: Evidence for mutant ALDH2*2
homozygosity as completely alcohol-rejecting gene status. (European Society for
Biomedical Research on Alcoholism Nordmann Award
Meeting: Interaction of Alcohol and Drugs, Vienna, Austria, 17-18 October 1996.)
8.
Genetic polymorphism and activity of human liver alcohol and aldehyde
dehydrogenases: Inference for first-pass metabolism of ethanol. (In Symposium:
Molecular Aspects of Alcohol Metabolism, 6th Congress of the European Society
for Biomedical Research on Alcoholism, Stockholm, Sweden, 28 June-1 July 1997.)
9.
Steady-state kinetic mechanism of human alcohol dehydrogenase family.
Implications for functional classification and ethanol/retinol metabolism. (9th
International Symposium on the Enzymology and Molecular Biology of Carbonyl
Metabolism, Varallo Sesia,
Italy, 20-24 June 1998.)
10.
Allelic variation of the alcohol dehydrogenase genes and alcoholism in
Asians. (In Symposium: Molecular Biology of the Alcohol Dehydrogenases, 9th
Congress of the International Society for Biomedical Research on Alcoholism,
Copenhagen, Denmark, 27 June-2 July 1998.)
11.
Interaction of functional polymorphisms of alcohol metabolic genes and
alcohol metabolism in Asian alcoholics. (1999 International Titisee
Symposium on Heath Effects of Alcohol Intake, Black Forest, Germany, 9-12 December 1999.)
12.
ALDH2 polymorphism and alcohol metabolism. (In Symposium: Genetic and
Environmental Influences on Alcohol Metabolism in Humans, 23rd Annual
Scientific Meeting of the Research Society on Alcoholism, Denver, U.S.A., 24-29 June 2000.)
13.
Dominance of human ALDH2*2 variant gene allele:
Influence on liver enzyme activity/content, alcohol pharmacokinetics, and
susceptibility to alcoholism. (10th International Symposium on the Enzymology
and Molecular Biology of Carbonyl Metabolism, Taos, New Mexico, U.S.A., 1-5 July 2000.)
14.
Alcohol dehydrogenase family and first-pass metabolism of ethanol. (In
Symposium: Basic and Clinical Aspects of Gastrointestional
Metabolism of Ethanol, 8th Congress of the European Society for Biomedical
Research on Alcoholism, Paris, France, 15-18 September 2001.)
15.
Kinetic mechanism of human class IV alcohol dehydrogenase (ADH4)
functioning as retinol dehydrogenase: Relevance for perturbation of retinoic
acid synthesis by ethanol consumption. (11th International Meeting on
Enzymology and Molecular Biology of Carbonyl Metabolism, Ystad,
Sweden, 2-6 July 2002.)
16.
The human ADH family: Enzymology and metabolism of ethanol and retinol.
(In Symposium: Interaction of Alcohol and Retinoids:
Basic and Clinical Aspects, 9th Congress of the European Society for Biomedical
Research on Alcoholism, Prague, Czech, 11-14 September 2003.)
17.
Pharmacogenetic determinants of alcohol metabolism and alcoholism in
human alcohol dehydrogenase family. (12th International Meeting on Enzymology and
Molecular Biology of Carbonyl Metabolism, Burlington, Vermont, U.S.A., 6-10 July 2004.)
18.
Physiological basis for full versus partial protection against alcoholism
in Asians. (In Symposium: Acetaldehyde and Alcoholism: Basic and Clinical
Perspectives, 10th Congress of the European Society for Biomedical Research on
Alcoholism, Canterbury, U.K., 4-7 September 2005.)
19.
Functional roles of alcohol dehydrogenase family in human ethanol
metabolism. (13th International Meeting on Enzymology and Molecular Biology of
Carbonyl Metabolism, Nashville, Indiana, U.S.A., 11-15 July 2006.)
20.
Acetaldehyde, polymorphisms and the cardiovascular system. (Novartis
(formerly Ciba) Foundation Symposium No. 285. Acetaldehyde-related Pathology:
Bridging the Trans-disciplinary Divide, London, U.K., 5-7 September 2006.)
21.
Polymorphisms in ADH/ALDH genes and the phenotypic correlations (In
Symposium: Genetic Approaches to Alcohol Dependency, 11th Congress of the
European Society for Biomedical Research on Alcoholism, Berlin, Germany, 23-26 September 2007.)
22.
Pharmacokinetic and pharmacodynamic effects of
acetaldehyde in ALDH2*2 alcoholics. (In Symposium: Acetaldehyde,
Alcohol-induced Behaviours and Alcoholism: Clinical
and Experimental Perspectives, 11th Congress of the European Society for Biomedical
Research on Alcoholism, Berlin, Germany, 23-26 September 2007.)
23.
Polymorphism of alcohol-metabolism genes and alcoholism in Taiwanese:
Correlation of the allelic variations with the pharmacokinetic and pharmacodynamic effects of acetaldehyde. (In Symposium:
Alcohol Research in Asian Pacific Countries, Joint Scientific Meeting of 19th
Conference of the Japanese Society for Psychiatric Research on Alcoholism, 42nd
Conference of the Japanese Medical Society of Alcohol and Drug Studies, and
10th Conference of the Japanese Forum on Nicotine and Drug Dependence Studies, Ohtsu, Japan, 28-29 September 2007.)
24.
Pharmacokinetic and pharmacodynamic effects of
acetaldehyde in Asian alcoholics carrying the variant ALDH2*2 gene allele. (In Symposium:
Genetic Determinants of Subjective and Physiological Responses to Ethanol and
the Risk for Alcohol Use Disorders in Asians, Joint Congress of 31st Annual
Scientific Meeting of the Research Society on Alcoholism and 14th Congress of
the International Society for Biomedical Research on Alcoholism, Washington,
DC, U.S.A., 27 June-2 July 2008.)
25.
Polymorphism of ethanol-metabolism genes and alcoholism in Asians:
Correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. (14th International Meeting
on Enzymology and Molecular Biology of Carbonyl Metabolism, Kranjska
Gora, Slovenia, 8-12 July 2008.)
26.
Pharmacogenetics of human ethanol metabolism and
alcoholism. (3rd Asia-Pacific City Forum of Biomedical Laboratory Science, Taipei,
1-2 May 2010.)
27. Quantitative
interpretation of steady-state ethanol metabolism in perfused rat liver using
the kinetic mechanism-based rate equations of alcohol dehydrogenase. (15th
International Meeting on Enzymology and Molecular Biology of Carbonyl
Metabolism, Lexington, U.S.A., 6-11
July 2010.)
28. Pharmacokinetics
and the brain hemodynamic and subjective perception effects of acetaldehyde in
heterozygous ALDH2*1/*2 alcoholics. (In ESBRA-APSAAR
Joint Symposium: Morphological Alterations in the Brain of Alcoholics, 13th
Congress of the European Society for Biomedical Research on Alcoholism, Vienna,
Austria, 4-7
September 2011.)
29.
Expression
pattern, activities and protein contents of alcohol and aldehyde dehydrogenases
in human liver: Assessment of hepatic first-pass metabolism of ethanol. (16th
International Meeting on Enzymology and Molecular Biology of Carbonyl
Metabolism, Ploen, Germany, 10-14
July 2012.)
B.
Organizer/chair of symposia in international conferences
1.
Chairs: Jan-Olov Hoog,
Sweden, and Shih-Jiun Yin, Taiwan
Symposium: Molecular Aspects of Alcohol Metabolism (in 6th Congress of the
European Society for Biomedical Research on Alcoholism, Stockholm, Sweden, 28
June-1 July 1997)
2.
Chair: Shih-Jiun Yin, Taiwan
Fourth Session of Aldehyde Dehydrogenase (in 10th International Symposium on
the Enzymology and Molecular Biology of Carbonyl Metabolism, Taos, New Mexico,
U.S.A., 1-5 July 2000)
3.
Organizer: Shih-Jiun Yin, Taiwan; Co-organizers:
Albert Y. Sun, U.S.A., and Ting-Kai Li, U.S.A.
International Symposium on Recent Advances in Biomedical Research on
Alcoholism: Genetics, Neurobiology, Behavior, and Disease (29 invited speakers:
5 from Europe, 6 from Asia, 18 from U.S.A.; 9-11 July 2000; Taipei, Taiwan, Republic of China;
sponsored by the National Health Research Institutes, the National Science
Council and the National Defense Medical Center)
4.
Chairs: Helmut K. Seitz, Germany, and Shih-Jiun
Yin, Taiwan
Symposium: Basic
and Clinical Aspects of Gastrointestinal Metabolism of Ethanol (in 8th Congress
of the European Society for Biomedical Research on Alcoholism, Paris, France,
15-18 September 2001)
5.
Organizers and Chairs: Thomas M. Badger, U.S.A., and Shih-Jiun Yin, Taiwan
Symposium: Alcohol Metabolism: Role in Toxicity and Carcinogenesis (in Joint
Meeting of 25th Annual Scientific Meeting of the Research Society on Alcoholism
and 11th Congress of the International Society for Biomedical Research on
Alcoholism, San Francisco, U.S.A., 28 June-3 July 2002)
6.
Chair: Shih-Jiun Yin, Taiwan
First Session of Alcohol Dehydrogenase (in 11th International Meeting on
Enzymology and Molecular Biology of Carbonyl Metabolism, Ystad,
Sweden, 2-6 July 2002)
7.
Chairs: Shih-Jiun Yin, Taiwan, and Helmut K.
Seitz, Germany
Symposium: Interaction of Alcohol and Retinoids:
Basic and Clinical Aspects (in 9th Congress of the European Society for
Biomedical Research on Alcoholism, Prague, Czech, 11-14 September 2003)
8.
Chair: Shih-Jiun Yin, Taiwan
First Session of Alcohol Dehydrogenase (in 12th International Meeting on
Enzymology and Molecular Biology of Carbonyl Metabolism, Burlington, Vermont,
U.S.A., 6-10 July 2004)
9.
Chairs: Shih-Jiun Yin, Taiwan, and Mikko Salaspuro, Finland
Symposium: Acetaldehyde and Alcoholism: Basic and Clinical Perspectives (in
10th Congress of the European Society for Biomedical Research on Alcoholism,
Canterbury, U.K., 4-7 September 2005)
10.
Chair: Shih-Jiun Yin, Taiwan
Second Session of Alcohol Dehydrogenase (in 13th International Meeting on
Enzymology and Molecular Biology of Carbonyl Metabolism, Nashville, Indiana,
U.S.A., 11-15 July 2006)
11.
Chairs: Etienne Quertemont, Belgium, and Shih-Jiun Yin, Taiwan
Symposium: Acetaldehyde, Alcohol-induced Behaviours
and Alcoholism: Clinical and Experimental Perspectives (in 11th Congress of the
European Society for Biomedical Research on Alcoholism, Berlin, Germany, 23-26 September 2007)
12. Chairs: Shih-Jiun Yin, Taiwan,
and Sung-Gon Kim, Korea
Symposium: Clinical Perspectives on Genetic Polymorphism of Alcohol-metabolism Genes
and Alcoholism (in 1st Congress of the Asia-Pacific Society for Alcohol and
Addiction Research, Seoul, Korea, 12-14 November 2009)
13. Chairs:
Shih-Jiun Yin, Taiwan, and Susumu Higuchi, Japan
Symposium: Genetic Polymorphism of Alcohol-Metabolism Genes and Alcoholism:
Recent Epidemiologic and Clinical Findings (in 2nd Congress of the Asia-Pacific
Society for Alcohol and Addiction Research, Bangkok, Thailand, 9-11
November 2011)
C. Editorial
board of international journals
1.
Assistant editor of Addiction Biology (an official journal of the Society
for the Study of Addiction to Alcohol and Other Drugs, U.K.; 1996-2004)
2.
Guest co-editor for a special issue of the Journal of Biomedical Science,
“Alcohol: Mode of Actions and Clinical Perspectives”, vol. 8, pp. 1-150, 2001 (published by S. Karger,
Basel, Switzerland)
3.
Member of editorial board of Alcoholism: Clinical and Experimental
Research (official journal of the Research Society on Alcoholism, U.S.A. and
the International Society for Biomedical Research on Alcoholism; 2008-2011)
4.
Member of board of field editors of th
Alcoholism: Clinical and Experimental Research (official journal of the
Research Society on Alcoholism, U.S.A. and the International Society for
Biomedical Research on Alcoholism; 2011-present)
D.
Board of directors of international scientific societies
1.
Asia-Pacific
Society for Alcohol and Addiction Research (founding member; 2008-2012)
2.
International
Society for Biomedical Research on Alcoholism (2010-2014)
◎Honors and Awards
· Research Grant
Awards (1985–2012, continuous without interruptions), National Science Council
of the Republic of China
· Excellent Research
Award (1990 and 1991), National Science Council of the Republic of China
· Outstanding Research
Award (2000), National Science Council of the Republic of China
◎Selected Publications of Original Articles (A–D)
and Reviews (E)
(Paper citations in parentheses from Web of
Science (WS) and Google Scholar (GS), accessed 27 February 2016; ≥ 40 citations,
high-impact papers suggested by intramural assessment, NIH, USA)
A. Genetics of alcohol metabolism and alcoholism
·
Yin, S.-J., Bosron,
W. F., Li, T.-K., Ohnishi, K., Okuda, K., Ishii, H. and Tsuchiya, M. (1984) Polymorphism
of human liver alcohol dehydrogenase: Indentification
of ADH2 2-1 and ADH2 2-2 phenotypes in the Japanese by
isoelectric focusing. Biochem. Genet. 22:169-180. (Citations: WS 40/GS
32)
·
Yin, S.-J., Cheng, T.-C., Chang, C.-P.,
Chen, Y.-J., Chao, Y.-C., Tang, H.-S., Chang, T.-M. and
Wu, C.-W. (1988) Human stomach alcohol and aldehyde dehydrogenases (ALDH): A
genetic model proposed for ALDH III isoenzymes. Biochem.
Genet. 26:343-360. (Citations: WS 36/GS 40)
· Thomasson, H. R., Edenberg, H.
J., Crabb, D. W., Mai, X.-L., Jerome, R. E., Li,
T.-K., Wang, S.-P., Lin, Y.-T., Lu, R.-B. and Yin,
S.-J. (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in
Chinese men. Am. J. Hum. Genet. 48:677-681. (Citations:
WS 443/GS 570)
·
Thomasson, H. R., Crabb,
D. W., Edenberg, H. J., Li, T.-K., Hwu, H.-G., Chen, C.-C., Yeh,
E.-K. and Yin, S.-J. (1994) Low frequency of
the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders.
Alcohol. Clin. Exp. Res. 18:640-643. (Citations: WS 106/GS
117)
· Chao, Y.-C., Liou, S.-R.,
Chung, Y.-Y., Tang, H.-S., Hsu, C.-T., Li, T.-K. and Yin,
S.-J. (1994) Polymorphism of alcohol and aldehyde dehydrogenase genes and
alcoholic cirrhosis in Chinese patients. Hepatology 19:360-366. (Citations:
WS 144/GS 184)
· Chen, C.-C., Lu, R.-B., Chen, Y.-C., Wang, M.-F., Chang,
Y.-C., Li, T.-K. and Yin, S.-J. (1999)
Interaction between the functional polymorphisms of the alcohol-metabolism
genes in protection against alcoholism. Am. J. Hum. Genet. 65:795-807. (Citations:
WS 288/GS 382)
·
Lee, S.-L., Höög, J.-O. and Yin, S.-J.
(2004) Functionality of allelic variations in human alcohol dehydrogenase gene
family: Assessment of a functional window for protection against alcoholism.
Pharmacogenetics 14:725-732. (Citations:
WS 28/GS 41)
·
Lai, C.-L., Yao, C.-T., Chau, G.-Y., Yang,
L.-F., Kao, T.-Y., Chiang, C.-P. and Yin, S.-J.
(2014) Dominance of the inactive Asian variant over activity and protein
contents of mitochrondrial aldehyde dehydrogenase 2
in human liver. Alcohol. Clin. Exp. Res. 38:44–50.
(Citations: WS 7/GS 13)
·
Chiang, C.-P., Lai, C.-L., Lee, S.-P., Hsu,
W.-L., Chi, Y.-C., Gao, H.-W., Yao, C.-T., Chou, G.-Y.
and Yin, S.-J. (2016) Ethanol metabolizing
activities and isozyme protein contents of alcohol and aldehyde dehydrogenases
in human liver: Phenotypic traits of the ADH1B*2
and ALDH2*2 variant gene alleles. Pharmacogenet. Genomics 26:184‒195.
B. Enzymology, metabolism and systems toxicology of ethanol
·
Yin, S.-J.,
Bosron, W. F., Magnes, L.
J. and Li, T.-K. (1984) Human liver alcohol dehydrogenase: Purification and
kinetic characterization of the b2b2, b2b1, ab2, and b2g1 “Oriental”
isoenzymes. Biochemistry 23:5847-5853. (Citations: WS 120/GS 115)
·
Yin, S.-J., Wang, M.-F., Liao, C.-S., Chen, C.-M. and
Wu, C.-W. (1990) Identification of a human stomach alcohol dehydrogenase with
distinctive kinetic properties. Biochem. Int. 22:829-835. (Citations: WS 63/GS 82)
·
Yin, S.-J., Vagelopoulos, N., Wang, S.-L. and Jörnvall, H. (1991)
Structural features of stomach aldehyde dehydrogeanse
distinguish dimeric aldehyde dehydrogenase as a ‘variable’ enzyme: ‘Variable’ and ‘constant’ enzymes within the alcohol and aldehyde
dehydrogenase families. FEBS Lett. 283:85-88. (Citations: WS 40/GS 40)
·
Yin, S.-J., Liao, C.-S., Chen, C.-M., Fan, F.-T. and
Lee, S.-C. (1992) Genetic polymorphism and activities of human lung alcohol and
aldehyde dehydrogenases: Implications for ethanol metabolism and cytotoxicity. Biochem. Genet. 30:203-215. (Citations: WS 16/GS 36)
·
Yin, S.-J., Chou, F.-J., Chao, S.-F., Tsai, S.-F., Liao, C.-S., Wang, S.-L., Wu,
C.-W. and Lee, S.-C. (1993) Alcohol and aldehyde
dehydrogenases in human esophagus: Comparison with the stomach enzyme
activities. Alcohol. Clin. Exp. Res. 17:376-381. (Citations: WS 103/GS 103)
·
Yin, S.-J., Liao, C.-S., Lee, Y.-C., Wu, C.-W. and Jao, S.-W. (1994) Genetic polymorphism and activities of
human colon alcohol and aldehyde dehydrogenases: No gender and age differences.
Alcohol. Clin. Exp. Res. 18:1256-1260. (Citations: WS 46/GS 47)
·
Dong, Y.-J., Peng, T.-K. and Yin, S.-J.
(1996) Expression and activities of class IV alcohol dehydrogenase and class
III aldehyde dehydrogenase in human mouth. Alcohol 13:257-262. (Citations: WS 80/GS 90)
·
Yin, S.-J., Liao,
C-S., Wu, C.-W., Li, T.-T., Chen, L.-L., Lai, C.-L. and
Tsao, T.-Y. (1997) Human stomach alcohol and aldehyde
dehydrogenases: Comparison of expression pattern and activities in alimentary
tract. Gastroenterology 112:766-775. (Citations:
WS 86/GS 103)
·
Lai, C.-L.,
Chao, Y.-C., Chen, Y.-C., Liao, C.-S., Chen, M.-C., Liu, Y.-C. and Yin, S.-J. (2000) No sex and age influence on the
expression pattern and activities of human gastric alcohol and aldehyde
dehydrogenases. Alcohol. Clin. Exp. Res.
24:1625–1632. (Citations: WS 23/GS 27)
·
Lee, S.-L.,
Wang, M.-F., Lee, A.-I. and Yin, S.-J. (2003) The metabolic role of human ADH3 functioning as ethanol
dehydrogenase. FEBS Lett. 544:143–147. (Citations: WS 28/GS 45)
·
Lee, S.-L., Chau, G.-Y., Yao, C.-T., Wu, C.-W. and
Yin, S.-J. (2006) Functional assessment of human alcohol dehydrogenase
family in ethanol metabolism: Significance of first-pass metabolism. Alcohol. Clin. Exp. Res. 30:1132-1142. (Citations:
WS 57/GS 79)
·
Chiang, C.-P.,
Wu, C.-W., Lee, S.-P., Chung, C.-C., Wang, C.-W., Lee, S.-L., Nieh, S. and Yin, S.-J. (2009) Expression pattern,
ethanol-metabolizing activities, and cellular localization of alcohol and
aldehyde dehydrogenases in human pancreas: Implications for pathogenesis of
alcohol-induced pancreatic injury. Alcohol. Clin.
Exp. Res. 33:1059–1068. (Citations: WS 16/GS 23)
·
Yao, C.-T.,
Lai, C-L., Hsieh, H.-S., Chi, C.-W. and Yin, S.-J.
(2010) Establishment of steady-state metabolism of ethanol in perfused rat
liver: The quantitative analysis using kinetic mechanism-based rate equations
of alcohol dehydrogenase. Alcohol 44:541–551. (Citations: WS 10/GS 17)
·
Chiang, C.-P., Jao, S.-W.,
Lee, S.-P., Chen, P.-C., Chung, C.-C., Lee, S.-L., Nieh,
S. and Yin, S.-J. (2012) Expression pattern, ethanol-metabolizing
activities, and cellular localization of alcohol and aldehyde dehydrogenases in
human large bowel: Association of the functional polymorphisms of ADH and ALDH
genes with hemorrhoids and colorectal cancer. Alcohol 46:37–49. (Citations: WS 14/GS 34)
·
Chiang, C.-P., Wu, C.-W., Lee, S.-P., Ho, J.-L., Lee,
S.-L., Nieh, S. and Yin, S.-J. (2012)
Expression pattern, ethanol-metabolizing activities, and cellular localization
of alcohol and aldehyde dehydrogenases in human small intestine. Alcohol. Clin. Exp. Res. 36:2047–2058. (Citations: WS 9/GS 34)
·
Yao, C.-T.,
Lai, C.-L. and Yin, S.-J. (2015) Steady state
metabolism of ethanol in perfused rat livers treated with cyanamide:
Quantitative analysis of acetaldehyde effects on the metabolic flux rates.
Alcohol. Clin. Exp. Res. 39:798–807.
C. Pharmacokinetics and pharmacodynamics of ethanol/acetaldehyde/acetate
·
Peng, G.-S., Wang, M.-F., Chen, C.-Y., Luu,
S.-U., Chou, H.-C., Li, T.-K. and Yin, S.-J.
(1999) Involvement of acetaldehyde for full protection against alcoholism by
homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 9:463-476. (Citations: WS 94/GS 114)
·
Chen, Y.-C.,
Lu, R.-B., Peng, G.-S., Wang, M.-F., Wang. H.-K., Ko, H.-C., Chang, Y.-C., Lu, J.-J., Li, T.-K. and Yin, S.-J. (1999) Alcohol metabolism and
cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol. Clin. Exp. Res. 23:1853–1860. (Citations: WS 67/GS 87)
·
Peng, G.-S., Chen, Y.-C., Tsao, T.-P., Wang,
M.-F. and Yin, S.-J. (2007) Pharmacokinetic and
pharmacodynamic basis for partial protection against
alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet. Genomics 17:845-855. (Citations:
WS 37/GS 48)
·
Chen, Y.-C., Peng, G.-S., Tsao, T.-P., Wang,
M.-F., Lu, R.-B. and Yin, S.-J. (2009)
Pharmacokinetic and pharmacodynamic basis for
overcoming acetaldehyde-induced adverse reaction in Asian alcoholics,
heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet.
Genomics 19:588-599. (Citations:
WS 26/GS 48)
·
Peng, G.-S., Chen, Y.-C., Wang, M.-F., Lai, C.-L. and
Yin, S.-J. (2014) ALDH2*2 but
not ADH1B*2 is a causative variant
gene allele for Asian alcohol flushing after a low dose challenge: Correlation
of the pharmacokinetic and pharmacodynamic findings. Pharmacogenet. Genomics 24:607–617. (Citations: WS 6/GS 9)
D. Interactions between ethanol/retinol/toxic alcohols/drugs with human
alcohol and aldehyde dehydrogenases
·
Han, C.-L., Liao, C.-S., Wu, C-W., Hwong,
C.-L., Lee, A.-R. and Yin, S.-J. (1998)
Contribution to first-pass metabolism of ethanol and inhibition by ethanol for
retinol oxidation in human alcohol dehydrogenase family: Implications for
etiology of fetal alcohol syndrome and alcohol-related diseases. Eur. J. Biochem. 254:25-31. (Citations: WS 73/GS 88)
·
Chou, C.-F, Lai, C.-L., Chang, Y.-C., Duester,
G. and Yin, S.-J. (2002) Kinetic mechanism of human class IV alcohol dehydrogenase
functioning as retinol dehydrogenase. J. Biol. Chem. 277:25209-25216. (Citations: WS 32/GS 40)
·
Lee, S.-L., Shih, H.-T., Chi, Y.-C., Li. Y.-P. and
Yin, S.-J. (2011) Oxidation of methanol, ethylene glycol, and
isopropanol with human alcohol dehydrogenases and the inhibition by ethanol and
4-methylpyrazole. Chem. Biol. Interact. 191:26–31. (Citations: WS 13/GS 23)
·
Lai, C.-L., Li, Y.-P., Liu, C.-M., Hsieh, H.-S. and
Yin, S.-J. (2013) Inhibition of human alcohol and aldehyde
dehydrogenases by cimetidine and assessment of its effects on ethanol
metabolism. Chem. Biol. Interact. 202:275–282. (Citations: WS 7/GS 8)
·
Li, Y.-P., Liao, C.-L., Cheng, Y.-W., Wu, T.-L., Lee, S.-L., Liu, J.-K. and Yin, S.-J. (2013) Inhibition of human alcohol and
aldehyde dehydrogenases by acetaminophen: Assessment of the effects on
first-pass metabolism of ethanol. Alcohol 47:559–565. (Citations: WS 6/GS 10)
·
Lee, S.-L.,
Lee, Y.-P., Wu, M.-L., Chi, Y.-C., Liu, C.-M., Lai, C.-L. and
Yin, S.-J. (2015) Inhibition of human alcohol and aldehyde
dehydrogenases by aspirin and salicylate: Assessment of the effects on
first-pass metabolism of ethanol. Biochem. Pharmacol.
95:71–79. (Citations: WS 0/GS 1)
·
Chi, Y.-C., Lee, S.-L., Lai, C.-L., Lee, Y.-P., Lee, S.-P., Chiang, C.-P.,
and Yin, S.-J. (2016) Ethanol oxidation and the inhibition by drugs in
human liver, stomach and small intestine: Quantitative assessment with
numerical organ modeling of alcohol dehydrogenase isozymes. Chem. Biol.
Interact. 258:134‒141.
E. Selected book chapters and review articles
·
Yin, S.-J.
and Li, T.-K. (1989) Genetic polymorphism and
properties of human alcohol and aldehyde dehydrogenases: Implications for
ethanol metabolism and toxicity, in “Molecular Mechanisms of Alcohol:
Neurobiology and Metabolism,” G. Y. Sun, P. K. Rudeen,
W. G. Wood, Y.-H. Wei, and A. Y. Sun, eds., Humana Press,
·
Yin, S.-J.,
Wang, S.-L., Liao, C.-S. and Jörnvall, H. (1993)
Human high-Km aldehyde dehydrogenase (ALDH3): Molecular, kinetic and structural
features, in "Enzymology and Molecular Biology of Carbonyl Metabolism
4," H. Weiner, D. W. Crabb and T. G. Flynn,
eds., Plenum Press, New York, pp. 87-98.
(The book is Volume 328 of the Advances in Experimental Medicine and Biology,
1993). (Citations: WS 3/GS 10)
·
Yin, S.-J.
(1994) Alcohol dehydrogenase: Enzymology and metabolism. Alcohol Alcohol. 29
(Suppl. 2):113-119.
(The title of the Supplement is “The Biology of Alcohol Problems,” J. B.
Saunders and J. B. Whitfield, eds., Elsevier Science, Oxford, 1996). (Citations: WS 27/GS 53)
·
Yin, S.-J.,
Wang, M.-F., Han, C.-L. and Wang, S.-L. (1995)
Substrate binding pocket structure of human aldehyde dehydrogenases: A
substrate specificity approach, in “Enzymology and Molecular Biology of
Carbonyl Metabolism 5,” H. Weiner , R. S. Holmes and B. Wermuth,
eds., Plenum Press, New York, pp. 9-16.
(The book is Volume 372 of the Advances in Experimental Medicine and Biology,
1995). (Citations: WS 15/GS 18)
·
Yin, S.-J.,
Han, C.-L., Liao, C.-S. and Wu, C.-W. (1997)
Expression, activities and kinetic mechanism of human stomach alcohol
dehydrogenase: Inference for first-pass metabolism of ethanol in mammals, in
“Enzymology and Molecular Biology of Carbonyl Metabolism 6,” H. Weiner, D. W. Crabb and T. G. Flynn, eds., Plenum Press,
·
Yin, S.-J.,
Han, C.-L., Lee, A.-I. and Wu, C.-W. (1999) Human alcohol
dehydrogenase family: Functional classification, ethanol/retinol metabolism,
and medical implications, in “Enzymology and Molecular Biology of Carbonyl
Metabolism 7,” H. Weiner, E. Maser, D. W. Crabb and
R. Lindahl, eds., Kluwer Academic/Plenum Publishers,
New York, pp. 265–274. (The book is Volume 463 of the Advances in Experimental
Medicine and Biology, 1999). (Citations: WS 23/GS 40)
·
Duester,
G., Farrés, J., Felder, M. R., Holmes, R., Höög, J.-O., Parés, X., Plapp, B.
V., Yin, S.-J. and Jörnvall,
H. (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase
gene family. Biochem. Pharmacol.
58:389–395. (Citations: WS 171/GS 222)
·
Yin, S.-J.
and Agarwal, D. P. (2001) Functional polymorphism of
alcohol and aldehyde dehydrogenases: Alcohol metabolism, alcoholism, and
alcohol-induced organ damage, in “Alcohol in Health and Disease,” D. P. Agarwal
and H. K. Seitz, eds., Marcel Dekker,
·
Yin, S.-J.,
Chou, C.-F., Lai, C.-L., Lee, S.-L. and Han, C.-L (2003)
Human class IV alcohol dehydrogenase (ADH4): Kinetic mechanism, functional
roles and medical relevance. Chem. Biol. Interact.143–144:219–227 (This special
issue of the journal is entitled “Enzymology and Molecular Biology of Carbonyl
Metabolism 9”) (Citations: WS 26/GS 42)
·
Yin, S.-J.
and Peng, G.-S. (2005) Overview of ALDH polymorphism:
Relation to cardiovascular effects of alcohol, in “Comprehensive Handbook of
Alcohol Related Pathology,” V. R. Preedy and R. R.
Watson, eds., Vol. 1, Elsevier Academic Press,
·
Yin, S.-J.,
Lee, S.-L., Han, C.-L., Chou, C.-
·
Yin, S.-J.
and Peng, G.-S. (2007) Acetaldehyde, polymorphisms and
cardiovascular system, in “Acetaldehyde-related Pathology: Bridging the
Trans-disciplinary Divide,” Novartis (formerly Ciba) Foundation Symposia 285,
D. J. Chadwick and J. Goode, eds., John Wiley & Sons Ltd., Chichester, UK, pp. 52–63; Discussion, pp. 63–68. (Citations: WS 5/GS 5)
·
Yin, S.-J.,
Lee, S.-L.,
·
Chen, C.-C. and Yin, S-J. (2008) Alcohol abuse and related
factors in
·
Peng, G.-S. and Yin, S.-J. (2009) Effect of the allelic variants
of aldehyde dehydrogenase ALDH2*2 and
alcohol dehydrogenase ADH1B*2 on
blood acetaldehyde concentrations. Hum. Genomics 3:121–127. (Citations: WS 43/GS 56)
·
Chen, Y.-C,
Peng, G.-S., Wang, M.-F., Taso, T.-P. and Yin, S.-J. (2009) Polymorphism of
ethanol-metabolism genes and alcoholism: Correlation of allelic variations with
the pharmacokinetic and pharmacodynamic consequences.
Chem. Biol. Interact.178:2–7. (Citations: WS 54/GS 77)